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What Are the 3 Stages of Sepsis: Sepsis progresses through three stages: sepsis, severe sepsis, and septic shock. In the sepsis stage, the body exhibits a systemic inflammatory response to an infection, which may manifest as fever, increased heart rate, rapid breathing, and altered mental status. Severe sepsis occurs when sepsis leads to organ dysfunction or failure. Septic shock, the most critical stage, is characterized by extremely low blood pressure, compromised organ function, and the potential for life-threatening complications. Early recognition and immediate medical intervention are crucial to treat sepsis effectively and improve patient outcomes.